Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14531563 | 0.83 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7056699 | 0.83 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6898320 | 0.81 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL7058287 | 0.80 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL6923149 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL6923150 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL6925796 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL7417302 | 0.77 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6929636 | 0.77 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCTSD | |
| SCHEMBL6929386 | 0.77 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518306-B1 | PDE4 inhibitors particularly in regards to treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |