Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411876 | 0.98 | SIGMAR1 (0.51) | SIGMAR1EBPKDM1AMAOBLMNA | |
| SCHEMBL27632864 | 0.95 | SIGMAR1 (0.49) | SIGMAR1EBPKDM1AMAOBLMNA | |
| SCHEMBL10644129 | 0.91 | SIGMAR1 (0.51) | SIGMAR1EBPKDM1AMEN1KMT2A | |
| SCHEMBL30192046 | 0.89 | SIGMAR1 (0.53) | SIGMAR1EBPKDM1AMEN1KMT2A | |
| SCHEMBL9280563 | 0.88 | SIGMAR1 (0.44) | SIGMAR1EBPKDM1AMAOBMEN1 | |
| SCHEMBL7330436 | 0.88 | SIGMAR1 (0.44) | SIGMAR1EBPKDM1AMAOBMEN1 | |
| SCHEMBL7782450 | 0.80 | SIGMAR1 (0.51) | SIGMAR1EBPKDM1AMAOBLMNA | |
| SCHEMBL17603661 | 0.80 | KDM1A (0.44) | SIGMAR1KDM1AMAOBMEN1KMT2A | |
| SCHEMBL22175918 | 0.79 | SIGMAR1 (0.50) | SIGMAR1EBPKDM1ALMNA | |
| SCHEMBL7788011 | 0.79 | SIGMAR1 (0.54) | SIGMAR1EBPKDM1AMAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737547-B1 | Compositions containing and methods of using N-acyl-1H-aminoindenes | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-05-18 | — | — | US | disclosed |
| WO-2000038673-A1 | COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2000-07-06 | — | — | WO | disclosed |