Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.55 |
| ▸ | DNM2 | P50570 | 4/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925226 | 0.91 | TLR8 (0.50) | HRH4DNM2TLR8SOAT1MAPK14 | |
| SCHEMBL7108041 | 0.84 | KDM4E (0.56) | HRH4DNM2TLR8HCAR3ADRA1A | |
| SCHEMBL4562794 | 0.84 | HRH4 (0.48) | HRH4DNM2TLR8SOAT1MAPK14 | |
| SCHEMBL18386507 | 0.83 | KDM4E (0.58) | HRH4DNM2TLR8SOAT1ADRA1A | |
| SCHEMBL26686229 | 0.81 | DNM2 (0.50) | HRH4DNM2TLR8SOAT1HCAR3 | |
| SCHEMBL31690831 | 0.81 | GSK3B (0.53) | HRH4DNM2MAP4K4 | |
| SCHEMBL26686269 | 0.80 | JAK2 (0.50) | HRH4TLR8MAP4K4 | |
| SCHEMBL2961051 | 0.79 | HRH4 (0.48) | HRH4DNM2TLR8SOAT1HCAR3 | |
| SCHEMBL11344402 | 0.79 | NPC1 (0.48) | HRH4DNM2TLR8MAPK14KARS1 | |
| SCHEMBL11346869 | 0.79 | NPC1 (0.48) | HRH4DNM2TLR8MAPK14KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |