⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2815876 | 0.66 | — | — | |
| SCHEMBL18032691 | 0.63 | GSK3A (0.30) | — | |
| SCHEMBL6631684 | 0.60 | — | — | |
| SCHEMBL30786015 | 0.59 | GSK3A (0.36) | — | |
| SCHEMBL6436410 | 0.55 | — | — | |
| SCHEMBL1395959 | 0.55 | — | — | |
| SCHEMBL1395961 | 0.55 | — | — | |
| SCHEMBL4419957 | 0.55 | — | — | |
| SCHEMBL9223333 | 0.55 | GSK3A (0.36) | — | |
| SCHEMBL30517940 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-53111093-A | — | — | None | — | — | JP | disclosed |
| EP-2560973-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2016-11-16 | — | — | EP | disclosed |
| EP-2421870-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2016-03-09 | — | — | EP | disclosed |
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2522671-A2 | Modulators of 5-HT receptors and methods of use thereof | Abbott Laboratories (US) | 2012-11-14 | — | — | EP | disclosed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |
| EP-1463731-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | Abbott GmbH & Co. KG (DE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003057699-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| EP-1089977-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067219-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |
| JP-S53111093-A | IMIDAZO(1,5-D)(1,4)BENZODIAZEPIN DERIVATIVE AND ITS PREPARATION | TAKEDA CHEM IND LTD | 1978-09-28 | — | — | JP | disclosed |
| US-3869450-A | S-triazolo (4,3-d) (1,4) benzodiazepin-6(7H)-ones | SANDOZ AG | 1975-03-04 | — | — | US | disclosed |