⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956378 | 0.76 | — | — | |
| SCHEMBL4860351 | 0.74 | — | — | |
| SCHEMBL18032691 | 0.74 | GSK3A (0.30) | — | |
| SCHEMBL18327710 | 0.71 | — | — | |
| SCHEMBL2730082 | 0.69 | — | — | |
| SCHEMBL692412 | 0.66 | — | — | |
| SCHEMBL2702775 | 0.65 | — | — | |
| SCHEMBL4419957 | 0.64 | — | — | |
| SCHEMBL26724388 | 0.64 | — | — | |
| SCHEMBL89327 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516435-A1 | INHIBITORS OF AKT ACTIVITY | Almac Discovery Limited (GB) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011077098-A9 | INHIBITORS OF AKT ACTIVITY | ALMAC DISCOVERY LIMITED (GB) | 2012-04-19 | — | — | WO | disclosed |
| WO-2010077663-A2 | SUBSTITUTED TETRACYCLIC 1H-INDENO (1,2-B) PYRIDINE-2 (5H)-ONE ANALOGS THEREOF AND USES THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-1017677-A1 | 4-PHENYLTETRAHYDROCHINOLINE UTILIZED AS AN INHIBITOR OF THE CHOLESTEROL ESTER TRANSFER PROTEIN | Bayer Aktiengesellschaft (DE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015504-A1 | 4-PHENYLTETRAHYDROCHINOLINE UTILIZED AS AN INHIBITOR OF THE CHOLESTEROL ESTER TRANSFER PROTEIN | BAYER AKTIENGESELLSCHAFT (DE) | 1999-04-01 | — | — | WO | disclosed |