Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.61 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30999724 | 0.83 | ALDH1A1 (0.47) | ESR1CA12CA9CA1CA2 | |
| N-Phenyl-Phthalimide SCHEMBL123618 | 0.81 | KMT2A (0.68) | ESR1HSPA1APABPC1NR1H3CA12 | |
| N-Phenyl-Phthalimide SCHEMBL29819622 | 0.81 | KMT2A (0.68) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL19773976 | 0.81 | KMT2A (0.68) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL28086894 | 0.81 | ESR1 (0.59) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL29710393 | 0.81 | ESR1 (0.59) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL29710383 | 0.81 | CA9 (0.66) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL9633890 | 0.81 | CA9 (0.66) | ESR1HSPA1APABPC1NR1H3CA12 | |
| SCHEMBL25776876 | 0.80 | BRD4 (0.59) | ESR1KMT2AMEN1GAAPKM | |
| N-Phenyl-Phthalimide SCHEMBL27271803 | 0.79 | KMT2A (0.65) | ESR1HSPA1APABPC1NR1H3CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |