Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 7/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 6/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960868 | 0.91 | PRKD1 (0.55) | PRKD1SIRT5CAMK2DPRKD3PRKD2 | |
| SCHEMBL6924745 | 0.84 | PRKD1 (0.54) | PRKD1PRKD3PRKD2FYN | |
| SCHEMBL6922488 | 0.82 | PRKD1 (0.62) | PRKD1PRKD3PRKD2 | |
| SCHEMBL966138 | 0.82 | PRKD1 (0.62) | PRKD1PRKD3PRKD2 | |
| SCHEMBL6922447 | 0.82 | PRKD1 (0.53) | PRKD1PRKD3PRKD2 | |
| SCHEMBL937644 | 0.81 | NPC1 (0.67) | PRKD1PRKD3PRKD2 | |
| SCHEMBL6923851 | 0.81 | PRKD1 (0.63) | PRKD1PRKD3PRKD2 | |
| SCHEMBL6923793 | 0.79 | PRKD1 (0.55) | PRKD1PRKD3PRKD2 | |
| SCHEMBL6923923 | 0.79 | PRKD1 (0.82) | PRKD1PRKD3PRKD2ROCK2ROCK1 | |
| SCHEMBL937989 | 0.78 | PRKD1 (0.75) | PRKD1PRKD3PRKD2FYNHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |