Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 8/20 | 0.63 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923851 | 0.91 | PRKD1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6922488 | 0.89 | PRKD1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL966138 | 0.89 | PRKD1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6923923 | 0.85 | PRKD1 (0.82) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL959797 | 0.85 | PRKD1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL959372 | 0.84 | TP53 (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6923596 | 0.83 | PRKD1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL957994 | 0.82 | PRKD1 (0.81) | ALDH1A1PRKD1PRKD3PRKD2MAPT | |
| SCHEMBL6924477 | 0.81 | PRKD1 (0.56) | PRKD1PRKD3PRKD2 | |
| SCHEMBL964036 | 0.81 | PRKD1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |