Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.58 |
| ▸ | RB1 | P06400 | 7/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18085037 | 0.86 | BRD3 (0.56) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL16941531 | 0.84 | CDKN1A (0.72) | RB1SIRT1SIRT2CDKN1A | |
| SCHEMBL13751063 | 0.82 | BRD3 (0.61) | BRD3RB1SIRT1SIRT2HTR7 | |
| SCHEMBL12107784 | 0.81 | BRD3 (0.50) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL832934 | 0.81 | SIRT1 (0.60) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL1200756 | 0.79 | BRD3 (0.57) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL13751061 | 0.78 | BRD3 (0.56) | BRD3RB1SIRT1SIRT2HTR7 | |
| SCHEMBL29625801 | 0.77 | BRD3 (0.67) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL4191431 | 0.77 | RB1 (0.62) | GRIN2BBRD3RB1SIRT1SIRT2 | |
| SCHEMBL10754574 | 0.77 | BRD3 (0.55) | BRD3RB1SIRT1SIRT2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1169789-C | Aminoalkoxy carbazoles for the treatment of CNS diseases | 法玛西雅厄普约翰美国公司 | 2004-10-06 | — | — | CN | disclosed |
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| CN-1372547-A | Aminoalkoxy carbazoles for the treatment of CNS diseases | UPJOHN CO (US) | 2002-10-02 | — | — | CN | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |