Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924656 | 1.00 | ATM (0.40) | ATMCYP2C9CYP2C19KMT2APLA2G10 | |
| SCHEMBL6924658 | 1.00 | ATM (0.40) | ATMCYP2C9CYP2C19KMT2APLA2G10 | |
| SCHEMBL7033111 | 0.91 | ITGB3 (0.43) | ATMCYP2C9CYP2C19KMT2AELANE | |
| SCHEMBL7034269 | 0.91 | ITGB3 (0.43) | ATMCYP2C9CYP2C19KMT2AELANE | |
| Hydrochloric Acid SCHEMBL6701572 | 0.90 | ITGB3 (0.42) | ATMKMT2AELANEFNTAFNTB | |
| Hydrochloric Acid SCHEMBL6701564 | 0.90 | ITGB3 (0.42) | ATMKMT2AELANEFNTAFNTB | |
| SCHEMBL6758440 | 0.89 | ATM (0.46) | ATMCYP2C9CYP2C19KMT2AELANE | |
| SCHEMBL4383512 | 0.89 | ATM (0.46) | ATMCYP2C9CYP2C19KMT2AELANE | |
| SCHEMBL6758441 | 0.89 | ATM (0.46) | ATMCYP2C9CYP2C19KMT2AELANE | |
| SCHEMBL6481590 | 0.88 | CYP19A1 (0.43) | ATMCYP2C9CYP2C19KMT2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514952-B1 | Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 2003-02-04 | — | — | US | disclosed |
| US-5998447-A | ANTIINFLAMMATORY AGENTS | HOECHST AKTIENGESELLSCHAFT AG (DE) | 1999-12-07 | — | — | US | disclosed |