Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 7/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925466 | 0.89 | ATM (0.55) | FABP4HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL6924568 | 0.88 | FABP4 (0.51) | FABP4HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL6923369 | 0.87 | FABP4 (0.50) | FABP4HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL6921111 | 0.80 | CSNK2A2 (0.53) | FABP4HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL6920465 | 0.78 | HDAC1 (0.64) | HDAC1HDAC6PTGS1PTGS2HTT | |
| SCHEMBL6923513 | 0.77 | HDAC1 (0.76) | HDAC1HDAC6PTGS1PTGS2HTT | |
| SCHEMBL6925034 | 0.76 | CSNK2A2 (0.54) | FABP4HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL6926059 | 0.74 | PTGS1 (0.67) | HDAC1HDAC6PTGS1PTGS2HTT | |
| SCHEMBL6691727 | 0.73 | FABP4 (0.74) | FABP4HDAC1HDAC6FABP3CSNK2A2 | |
| SCHEMBL6685674 | 0.73 | FABP4 (0.74) | FABP4FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |