Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.40 |
| ▸ | RXRB | P28702 | 4/20 | 0.40 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
| ▸ | RARG | P13631 | 3/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870763 | 0.93 | RXRA (0.43) | RXRARXRBRXRGRARGHNF4A | |
| SCHEMBL6928615 | 0.93 | RXRA (0.43) | RXRARXRBRXRGRARGBACE1 | |
| SCHEMBL6927632 | 0.87 | RXRA (0.44) | RXRARXRBRXRGRARGBACE1 | |
| SCHEMBL6927451 | 0.86 | RXRA (0.42) | RXRARXRBRXRGRARGBACE1 | |
| SCHEMBL6879674 | 0.85 | RXRA (0.47) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6870970 | 0.77 | RXRA (0.48) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6876540 | 0.77 | RXRA (0.47) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6876425 | 0.76 | RXRA (0.53) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6874284 | 0.76 | RXRA (0.50) | RXRARXRBRXRGRARGBACE1 | |
| SCHEMBL6926719 | 0.75 | RXRA (0.48) | RXRARXRBRXRGRARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515021-B1 | Bicyclic aromatic compounds | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2003-02-04 | — | — | US | disclosed |