Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.47 |
| ▸ | CTSE | P14091 | 1/20 | 0.47 |
| ▸ | PGC | P20142 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709659 | 0.77 | REN (0.57) | REN | |
| SCHEMBL5709573 | 0.76 | REN (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6925430 | 0.72 | REN (0.60) | REN | |
| SCHEMBL7491046 | 0.71 | REN (0.60) | REN | |
| SCHEMBL7311911 | 0.71 | REN (0.57) | REN | |
| SCHEMBL5709565 | 0.71 | REN (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9249864 | 0.71 | REN (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5709582 | 0.70 | REN (0.59) | REN | |
| SCHEMBL5709629 | 0.70 | REN (0.60) | REN | |
| SCHEMBL5709600 | 0.69 | REN (0.66) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515025-B2 | Renin inhibitor | PHARMACIA CORPORATION | 2003-02-04 | — | — | US | disclosed |