Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927138 | 0.90 | GRM5 (0.55) | GRM5PTGS1ALOX15TSHRCASP1 | |
| SCHEMBL6927261 | 0.88 | GRM5 (0.73) | GRM5 | |
| SCHEMBL6924962 | 0.88 | GRM5 (0.76) | GRM5 | |
| SCHEMBL12416348 | 0.85 | GRM5 (0.56) | GRM5ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL12416693 | 0.85 | GRM5 (0.68) | GRM5 | |
| SCHEMBL6927436 | 0.85 | GRM5 (0.80) | GRM5 | |
| SCHEMBL6926154 | 0.80 | GRM5 (0.77) | GRM5 | |
| SCHEMBL6925820 | 0.80 | GRM5 (0.76) | GRM5 | |
| SCHEMBL6927500 | 0.79 | GRM5 (0.77) | GRM5 | |
| SCHEMBL6927556 | 0.78 | GRM5 (0.69) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035174-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |