Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.64 |
| ▸ | PIM1 | P11309 | 3/20 | 0.64 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926478 | 1.00 | AKR1B1 (0.64) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6925746 | 0.97 | PIM1 (0.69) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6925745 | 0.97 | PIM1 (0.69) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6928730 | 0.91 | PIM1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6928727 | 0.91 | PIM1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6927790 | 0.89 | AKR1B1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6927012 | 0.89 | PIM1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6927009 | 0.89 | PIM1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6927788 | 0.89 | AKR1B1 (0.58) | AKR1B1PIM1PIM2NPC1RAB9A | |
| SCHEMBL6928982 | 0.89 | HPGD (0.68) | AKR1B1PIM1PIM2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |