Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 4/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MRE11 | P49959 | 1/20 | 0.47 |
| ▸ | NAT1 | P18440 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927788 | 1.00 | AKR1B1 (0.58) | AKR1B1HPGDRAB9ATDP1GSK3B | |
| SCHEMBL6928730 | 0.89 | PIM1 (0.58) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6928727 | 0.89 | PIM1 (0.58) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6927009 | 0.89 | PIM1 (0.58) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6926478 | 0.89 | AKR1B1 (0.64) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6926481 | 0.89 | AKR1B1 (0.64) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6927012 | 0.89 | PIM1 (0.58) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6928982 | 0.89 | HPGD (0.68) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6928986 | 0.89 | HPGD (0.68) | AKR1B1HPGDRAB9APIM1PIM2 | |
| SCHEMBL6927204 | 0.87 | AKR1B1 (0.59) | AKR1B1HPGDRAB9ATDP1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |