Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246338 | 0.86 | KMT2A (0.53) | KMT2AMEN1KCNK3KCNK9KCNH2 | |
| SCHEMBL6923975 | 0.81 | KMT2A (0.56) | KMT2AMEN1KCNK3KCNK9KCNH2 | |
| SCHEMBL6924665 | 0.73 | PLAU (0.56) | KMT2ANPC1RAB9ATP53MAPT | |
| SCHEMBL13709501 | 0.72 | PLAU (0.54) | NPC1RAB9APARP1 | |
| SCHEMBL6923971 | 0.72 | ALDH1A1 (0.54) | KMT2AMEN1KCNK3KCNK9KCNH2 | |
| SCHEMBL6920041 | 0.72 | MEN1 (0.56) | KMT2AMEN1KCNK3KCNK9ALDH1A1 | |
| SCHEMBL6924791 | 0.72 | C1S (0.53) | — | |
| SCHEMBL21974461 | 0.70 | KMT2A (0.68) | KMT2AMEN1KCNK3KCNK9KCNH2 | |
| SCHEMBL20393318 | 0.70 | KMT2A (0.73) | KMT2AMEN1KCNK3KCNK9KCNH2 | |
| SCHEMBL18773840 | 0.70 | KMT2A (0.84) | KMT2AMEN1KCNK3KCNK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515002-B2 | 4-(4-(1-phenyl-5-propylpyrazol4-yl)(1,3-thiazol-2-yl))-5 -methylthiothiophene-2-carboxamidine, for example; complement inhibitors; treating tissue damage, inflammation, or autoimmune diseases | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-02-04 | — | — | US | disclosed |