⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295022 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL4881159 | 0.83 | TSHR (0.33) | — | |
| SCHEMBL510037 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL3151320 | 0.80 | CYP3A4 (0.33) | — | |
| SCHEMBL509694 | 0.78 | LMNA (0.30) | — | |
| SCHEMBL1680269 | 0.76 | TSHR (0.42) | — | |
| SCHEMBL1680605 | 0.76 | TSHR (0.32) | — | |
| SCHEMBL17819275 | 0.74 | — | — | |
| SCHEMBL17781255 | 0.74 | TSHR (0.33) | — | |
| SCHEMBL28500589 | 0.74 | CYP3A4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339765-A1 | SOL-GEL PARTICLES INCLUDING HOMOGENEOUSLY DISPERSED DOPANTS AND RELATED METHODS AND SYSTEMS | UNITED STATES DEPARTMENT OF ENERGY | 2023-10-26 | — | — | US | disclosed |
| US-11472808-B2 | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2022-10-18 | — | — | US | disclosed |
| EP-3000810-B1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | ARRAY BIOPHARMA INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-1663210-B1 | BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2017-04-19 | — | — | EP | disclosed |
| EP-3000810-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | Array Biopharma, Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2275102-B1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | ARRAY BIOPHARMA INC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-8754101-B2 | N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists | GLAXO GROUP LIMITED (GB) | 2014-06-17 | — | — | US | disclosed |
| US-20140051720-A1 | N-Cyclobutyl - Imidazopyridine - Methylamine As TRPV1 Antagonists | GLAXO GROUP LIMITED (GB) | 2014-02-20 | — | — | US | disclosed |
| EP-2697221-A1 | N- CYCLOBUTYL - IMIDAZOPYRIDINE - METHYLAMINE AS TRPV1 ANTAGONISTS | Glaxo Group Limited (GB) | 2014-02-19 | — | — | EP | disclosed |
| US-8513293-B2 | Methods of treating a hyperproliferative disorder or inhibiting cell growth in a mammal | ARRAY BIOPHARMA INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-1353896-A2 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF HYDROXYLATED CYCLOBUTYLALKYLAMINES | Sepracor Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |
| US-20020115727-A1 | Synthesis, methods of using, and compositions of hydroxylated cyclobutylalkylamines | SEPRACOR INC. | 2002-08-22 | — | — | US | disclosed |
| WO-2002046138-A2 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF HYDROXYLATED CYCLOBUTYLALKYLAMINES | SEPRACOR INC. (US) | 2002-06-13 | — | — | WO | disclosed |
| EP-0743307-B1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO (JP) | 2001-09-12 | — | — | EP | disclosed |
| EP-0840728-A1 | HETEROARYL DIOL ACIDS AS LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1998-05-13 | — | — | EP | disclosed |
| US-5750539-A | ANTIASTHMATICS | MERCK FROSST CANADA (CA) | 1998-05-12 | — | — | US | disclosed |
| US-5739333-A | 4-SULFONAMIDO-6-ARYLOXY OR -AMINOALKYLENEOXY,-AMINO, OR -THIOPYRIMIDINES; ENDOLTHELIN ANTAGONISTS; HYPOTENSIVE AND ULCER AGENTS; ASTHMA; RAYNAUD DISEASE; CARDIOVASCULAR DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| WO-1996040638-A1 | HETEROARYL DIOL ACIDS AS LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0743307-A1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1996-11-20 | — | — | EP | disclosed |