Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599219 | 1.00 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL599220 | 1.00 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL599218 | 1.00 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL23163290 | 0.85 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL22122686 | 0.85 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL29277771 | 0.85 | MAPT (0.44) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4135838 | 0.84 | MAPT (0.47) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL28087182 | 0.84 | MAPT (0.47) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL28087184 | 0.84 | MAPT (0.47) | MAPTGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL599626 | 0.84 | MAPT (0.40) | MAPTGAATSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421370-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124055-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |