Citric Acid

Citric Acid

SCHEMBL692736

C[N+](C)(C)CCO.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Fe+3]

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BHRH2IMPA1

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.59
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP3A4 P08684 1/20 0.44
SLC5A7 Q9GZV3 1/20 0.44
BBOX1 O75936 3/20 0.33
GALR3 O60755 1/20 0.32
SLC22A16 Q86VW1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL20456925 1.00 CA4 (0.59) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL119893 1.00 CA4 (0.59) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL275858 1.00 CA4 (0.59) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL31726489 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL3871318 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL275857 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL3998452 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL15323424 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL3998443 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4
Citric Acid SCHEMBL1154430 0.98 CA4 (0.57) CA4MEN1LMNAKMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230363417-A1 PRODUCTS AND METHODS FOR INCREASING NITRIC OXIDE PRODUCTION AND MANAGING OXIDATIVE STRESS CORPORATION, KENT (US) 2023-11-16 US claimed
CN-110462054-B perfusion medium 勃林格殷格翰国际公司 2023-11-10 CN claimed
WO-2022040590-A1 PRODUCTS AND METHODS FOR INCREASING NITRIC OXIDE PRODUCTION AND MANAGING OXIDATIVE STRESS KENT CORPORATION (US) 2022-02-24 WO claimed
WO-2021137780-A1 PREPARATION OF FILM TABLET COMPOSITION COMPRISING HEME IRON FOR IRON DEFICIENCY İLKO İLAÇ SANAYİ VE TİCARET A.Ş. (TR) 2021-07-08 WO claimed
WO-2020187420-A1 COMPLEX IRON CONTAINING CULTURE MEDIUM FLORABIO TEKNOLOJI SANAYI VE TICARET A.S. (TR) 2020-09-24 WO claimed
US-9913806-B2 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron FE3 MEDICAL, INC. (US) 2018-03-13 US claimed
US-9731982-B2 Surface modified ceramic filter UNIVERSITY OF KANSAS (US) 2017-08-15 US claimed
EP-3103510-A1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS Incube Labs, Llc (US) 2016-12-14 EP claimed
EP-2320885-B1 PATCHES FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON FE3 MEDICAL INC (US) 2016-10-19 EP claimed
EP-2421601-B1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS INCUBE LABS LLC (US) 2016-06-15 EP claimed
US-20090035385-A1 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2009-02-05 US claimed
EP-1996030-A1 DOUBLE-FORTIFIED SALT AND PREPARATION PROCESS THEREFOR Akzo Nobel N.V. (NL) 2008-12-03 EP claimed
WO-2007107501-A1 DOUBLE-FORTIFIED SALT AND PREPARATION PROCESS THEREFOR AKZO NOBEL N.V. (NL) 2007-09-27 WO claimed
EP-1827418-A2 COMPOSITIONS INCLUDING IRON Drugtech Corporation (US) 2007-09-05 EP claimed
EP-1827419-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION Drugtech Corporation (US) 2007-09-05 EP claimed
WO-2006068697-A2 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
WO-2006068729-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
US-20060134227-A1 Compositions including iron DRUGTECH CORPORATION 2006-06-22 US claimed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO claimed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US claimed