Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL692736 | 1.00 | CA4 (0.59) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL20456925 | 1.00 | CA4 (0.59) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL275858 | 1.00 | CA4 (0.59) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL31726489 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL3871318 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL275857 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL3998452 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL15323424 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL3998443 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 | |
| Citric Acid SCHEMBL1154430 | 0.98 | CA4 (0.57) | CA4MEN1LMNAKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 901 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551441-B2 | Water soluble silicon-containing granulate | BIO MINERALS NV (BE) | 2026-02-17 | — | — | US | claimed |
| US-20260026538-A1 | COMPOSITIONS COMPRISING CHOLINE AND OMEGA-3 FATTY ACID TO NUTRITIONALLY ENHANCE FOOD PRODUCTS | INGENUITY FOODS, INC. (US) | 2026-01-29 | — | — | US | claimed |
| US-20250304851-A1 | METHODS AND COMPOSITIONS USED IN CONTROLLING FORMATION SAND PRODUCTION, PROPPANT FLOWBACK, AND FINES MIGRATION | HALLIBURTON ENERGY SERVICES, INC | 2025-10-02 | — | — | US | claimed |
| US-12426615-B2 | Compositions comprising choline and omega-3 fatty acid to nutritionally enhance food products | INGENUITY FOODS, INC. (US) | 2025-09-30 | — | — | US | claimed |
| CN-120022522-A | Drug-loaded microneedle, drug-loaded microneedle patch and electrically-controlled drug release microneedle system | 成都邦迈医创科技有限公司 | 2025-05-23 | — | — | CN | claimed |
| WO-2025088479-A1 | PROCESS FOR RECYCLING LITHIUM BATTERIES | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2025-05-01 | — | — | WO | claimed |
| CN-119896763-A | Pasty biological tissue adhesive capable of being coated and preparation method and application thereof | 哈尔滨工业大学 | 2025-04-29 | — | — | CN | claimed |
| CN-119556538-A | Alkaline stripping liquid for silicon-based surface composite film and stripping method thereof | 湖北兴福电子材料股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| US-20250059446-A1 | MULTIVALENT IONIC LIQUIDS AS PROCESS AIDS FOR BITUMEN EXTRACTION | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-02-20 | — | — | US | claimed |
| US-12171224-B2 | Choline salt and ammonium-free adjuvants for water conditioning and agricultural formulations | SPECIALTY OPERATIONS FRANCE (FR) | 2024-12-24 | — | — | US | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| CN-1290125-A | Enhancement of metal molluscicides by ethylene diamine disuccinic acid | NEUDORFF W GMBH KG (DE) | 2001-04-04 | — | — | CN | claimed |
| US-6048728-A | PROPAGATING CELLS; CONTACTING CELLS WITH A CULTURE MEDIUM, WHEREIN SAID COMPONENTS ARE SUFFICIENT TO INCREASE THE CULTURES PRODUCTIVE SHELF LIFE BY MAINTAINING CELLS IN A PROPAGATION STATE | CHIRON CORPORATION (US) | 2000-04-11 | — | — | US | claimed |
| US-5939076-A | Composition and method for treating or alleviating migraine headaches | ALLOCCA TECHICAL, INC. (US) | 1999-08-17 | — | — | US | claimed |
| WO-1999023881-A1 | COMPOSITION AND METHOD FOR PREVENTING OR ALLEVIATING MIGRAINE HEADACHES | ALLOCCA TECHNICAL, INC. (US) | 1999-05-20 | — | — | WO | claimed |
| EP-0435911-B1 | CELL CULTURE MEDIUM FOR ENHANCED CELL GROWTH, CULTURE LONGEVITY AND PRODUCT EXPRESSION | CETUS ONCOLOGY CORP (US) | 1996-03-13 | — | — | EP | claimed |
| EP-0501776-A1 | Stabilization of subterranean formations | HALLIBURTON COMPANY (US) | 1992-09-02 | — | — | EP | claimed |
| US-5097904-A | Flow control agents in enhanced oil recovery | HALLIBURTON COMPANY (US) | 1992-03-24 | — | — | US | claimed |
| EP-0435911-A1 | CELL CULTURE MEDIUM FOR ENHANCED CELL GROWTH, CULTURE LONGEVITY AND PRODUCT EXPRESSION. | CETUS CORP (US) | 1991-07-10 | — | — | EP | claimed |
| WO-1990003430-A1 | CELL CULTURE MEDIUM FOR ENHANCED CELL GROWTH, CULTURE LONGEVITY AND PRODUCT EXPRESSION | CETUS CORPORATION (US) | 1990-04-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12171224-B2 | Choline salt and ammonium-free adjuvants for water conditioning and agricultural formulations | ACHE, PHOSPHO1, CHAT | CA4 1172/4885MEN1 2734/4885LMNA 3927/4885 |
| US-12551441-B2 | Water soluble silicon-containing granulate | SI, GIPR, VIP | CA4 1064/4885MEN1 2488/4885LMNA 1265/4885 |
| US-20260026538-A1 | COMPOSITIONS COMPRISING CHOLINE AND OMEGA-3 FATTY ACID TO NUTRITIONALLY ENHANCE FOOD PRODUCTS | ELOVL3, ELOVL6, ELOVL1 | CA4 2963/4885MEN1 3184/4885LMNA 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.