Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethanolamine SCHEMBL11654955 | 0.86 | GSR (0.35) | GSRMEN1LMNAKMT2AKDM4E | |
| Diethanolamine SCHEMBL28560435 | 0.86 | GSR (0.38) | GSRMEN1LMNAKMT2AKDM4E | |
| Diethanolamine SCHEMBL21433690 | 0.84 | GSR (0.34) | GSRMEN1LMNAKMT2AKDM4E | |
| Diethanolamine SCHEMBL8149872 | 0.83 | GSR (0.39) | GSRMEN1LMNAKMT2AKDM4E | |
| Diethanolamine SCHEMBL29132363 | 0.80 | GSR (0.38) | GSRMEN1LMNAKMT2AKDM4E | |
| SCHEMBL1092722 | 0.80 | — | — | |
| Diethanolamine SCHEMBL28966838 | 0.79 | GSR (0.34) | GSRMEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL434887 | 0.78 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9751475 | 0.78 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL28308745 | 0.78 | GSR (0.36) | GSRMEN1LMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051406-A4 | SUPER-ABSORBING POLYMERIC NETWORKS | DONLAR CORP (US) | 2003-02-12 | — | — | EP | disclosed |
| EP-1051406-A1 | SUPER-ABSORBING POLYMERIC NETWORKS | DONLAR CORPORATION (US) | 2000-11-15 | — | — | EP | disclosed |
| US-5998491-A | CROSSLINKED POLYASPARTATIC ACID | DONLAR CORPORATION (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1999037624-A1 | SUPER-ABSORBING POLYMERIC NETWORKS | DONLAR CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |