Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL9751475 | 1.00 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9751476 | 1.00 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL19520453 | 0.90 | CA12 (0.48) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL10667807 | 0.85 | MEN1 (0.41) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6692329 | 0.80 | CA12 (0.56) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL11654955 | 0.80 | GSR (0.35) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL28560435 | 0.79 | GSR (0.38) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL6928183 | 0.78 | GSR (0.34) | MEN1LMNAKMT2A | |
| Diethanolamine SCHEMBL21433690 | 0.78 | GSR (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5429905 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051950-B1 | BINDER FOR MINERAL FIBRES | ROCKWOOL INT (DK) | 2019-10-09 | — | — | EP | disclosed |
| EP-2054354-B1 | AQUEOUS UREA-MODIFIED BINDER FOR MINERAL FIBRES | ROCKWOOL INT (DK) | 2018-10-03 | — | — | EP | disclosed |
| US-20150152262-A1 | BINDER FOR MINERAL FIBERS | ROCKWOOL INTERNATIONAL A/S (DK) | 2015-06-04 | — | — | US | disclosed |
| US-20130140481-A1 | BONDED MINERAL FIBRE PRODUCT HAVING HIGH FIRE AND PUNKING RESISTANCE | ROCKWOOL INTERNATIONAL A/S (DK) | 2013-06-06 | — | — | US | disclosed |
| EP-2596159-A1 | BONDED MINERAL FIBRE PRODUCT HAVING HIGH FIRE AND PUNKING RESISTANCE | Rockwool International A/S (DK) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010694-A1 | BONDED MINERAL FIBRE PRODUCT HAVING HIGH FIRE AND PUNKING RESISTANCE | ROCKWOOL INTERNATIONAL A/S (DK) | 2012-01-26 | — | — | WO | disclosed |
| EP-2059118-A1 | AQUEOUS BINDER COMPOSITION FOR MINERAL FIBRES | Rockwool International A/S (DK) | 2009-05-20 | — | — | EP | disclosed |
| EP-2054354-A1 | AQUEOUS UREA-MODIFIED BINDER FOR MINERAL FIBRES | Rockwool International A/S (DK) | 2009-05-06 | — | — | EP | disclosed |
| EP-2051950-A1 | BINDER FOR MINERAL FIBRES | Rockwool International A/S (DK) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008028923-A1 | AQUEOUS BINDER COMPOSITION FOR MINERAL FIBRES | ROCKWOOL INTERNATIONAL A/S (DK) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008023032-A1 | AQUEOUS UREA-MODIFIED BINDER FOR MINERAL FIBRES | ROCKWOOL INTERNATIONAL A/S (DK) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008020069-A1 | BINDER FOR MINERAL FIBRES | ROCKWOOL INTERNATIONAL A/S (DK) | 2008-02-21 | — | — | WO | disclosed |