SCHEMBL6928369

SCHEMBL6928369

CCc1ccc([C@H](O)COc2ccc(CC3SC(=O)NC3=O)cc2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARG P37231 14/20 1.00
CYP3A4 P08684 2/20 0.65
RXRA P19793 1/20 0.65
MPC2 O95563 1/20 0.64
CYP2C8 P10632 1/20 0.64
CYP2C9 P11712 1/20 0.64
FFAR1 O14842 5/20 0.51
PPARA Q07869 2/20 0.51
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
TP53 P04637 1/20 0.50
CYP1A2 P05177 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.50
KMT2A Q03164 1/20 0.50
HSD17B10 Q99714 1/20 0.50
TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2327405 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6929811 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL18541506 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL18541508 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL2328758 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL23836844 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL2328760 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL2266225 1.00 PPARG (1.00) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6931081 0.91 PPARG (0.83) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6930472 0.91 PPARG (0.83) PPARGCYP3A4RXRAMPC2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210038566-A1 USE OF MODULATORS OF NEET PROTEINS FOR THE TREATMENT OF INFECTION ENYO PHARMA (FR) 2021-02-11 US disclosed
EP-3202401-B1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CIRIUS THERAPEUTICS INC (US) 2019-10-23 EP disclosed
EP-2968298-B1 DEUTERIUM-ENRICHED 2,4-THIAZOLIDINEDIONES AND METHODS OF TREATMENT DEUTERX LLC (US) 2018-01-31 EP disclosed
EP-2513070-B1 PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES CIRIUS THERAPEUTICS INC (US) 2017-11-08 EP disclosed
EP-3202401-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES Octeta Therapeutics, LLC (US) 2017-08-09 EP disclosed
EP-2512470-B1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OCTETA THERAPEUTICS LLC (US) 2016-11-30 EP disclosed
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES CIRIUS THERAPEUTICS, INC. 2016-02-25 US disclosed
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES CIRIUS THERAPEUTICS, INC. 2016-02-25 US disclosed
US-9155729-B2 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) 2015-10-13 US disclosed
US-9155729-B2 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) 2015-10-13 US disclosed
WO-2011084453-A1 PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011084459-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF OBESITY AND OTHER METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011084456-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011075514-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-06-23 WO disclosed
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY 2009-06-04 US disclosed
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY 2009-06-04 US disclosed
US-20090143442-A1 Thiazolidinedione analogues ALZHEIMER DRUG DISCOVERY FOUNDATION 2009-06-04 US disclosed
US-20090143442-A1 Thiazolidinedione analogues ALZHEIMER DRUG DISCOVERY FOUNDATION 2009-06-04 US disclosed
US-20090137638-A1 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC 2009-05-28 US disclosed
US-20090137638-A1 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143442-A1 Thiazolidinedione analogues PPARD, GLP1R, PPARG PPARG 3/4885CYP3A4 727/4885RXRA 435/4885
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues GLP1R, PPARD, SLC5A2 PPARG 5/4885CYP3A4 1170/4885RXRA 218/4885
US-20210038566-A1 USE OF MODULATORS OF NEET PROTEINS FOR THE TREATMENT OF INFECTION PEBP1, ELANE, MME PPARG 4168/4885CYP3A4 4854/4885RXRA 3795/4885
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES PPARD, PPARG, PPARA PPARG 2/4885CYP3A4 685/4885RXRA 27/4885
US-20090137638-A1 Thiazolidinedione analogues SLC5A2, GLP1R, SLC5A1 PPARG 6/4885CYP3A4 1017/4885RXRA 346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.