Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928565 | 0.79 | GRM5 (0.79) | GRM5 | |
| SCHEMBL2193806 | 0.79 | GRM5 (0.60) | GRM5 | |
| SCHEMBL6929004 | 0.78 | GRM5 (0.59) | GRM5 | |
| SCHEMBL30635207 | 0.78 | GRM5 (0.59) | GRM5 | |
| SCHEMBL6928772 | 0.77 | GRM5 (0.59) | GRM5 | |
| SCHEMBL6929084 | 0.77 | GRM5 (0.83) | GRM5 | |
| SCHEMBL6927232 | 0.77 | GRM5 (0.80) | GRM5 | |
| SCHEMBL6929148 | 0.76 | GRM5 (0.65) | GRM5 | |
| SCHEMBL6928866 | 0.76 | KDR (0.64) | GRM5 | |
| SCHEMBL6927252 | 0.76 | GRM5 (0.78) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035186-A1 | SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |