Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205993 | 0.88 | SLC6A4 (0.49) | HRH3ESR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL18170322 | 0.85 | ESR1 (0.49) | HRH3ESR1DRD2SLC6A4KDM2B | |
| SCHEMBL18200131 | 0.84 | CARM1 (0.49) | HRH3ESR1DRD2SLC6A4SLC6A2 | |
| SCHEMBL6636548 | 0.83 | SIGMAR1 (0.45) | HRH3SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL5333626 | 0.83 | SIGMAR1 (0.45) | HRH3SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL5222212 | 0.82 | SLC6A4 (0.40) | ESR1SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL18170287 | 0.81 | HRH3 (0.45) | HRH3ESR1DRD2KDM2B | |
| SCHEMBL5218296 | 0.79 | HTR2C (0.37) | HRH3ESR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5218302 | 0.79 | ALPG (0.38) | HRH3SLC6A4SLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL6689767 | 0.78 | SIGMAR1 (0.39) | HRH3SLC6A4SLC6A2SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514961-B1 | Such as anxiety and all forms of epilepsy, particularly in humans | VERNALIS RESEARCH LIMITED (GB) | 2003-02-04 | — | — | US | disclosed |