Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6740232 | 0.79 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6742523 | 0.77 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL7032138 | 0.75 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6738043 | 0.74 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6738719 | 0.74 | — | — | |
| SCHEMBL6927785 | 0.73 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6739299 | 0.71 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7028959 | 0.70 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7035545 | 0.69 | — | — | |
| SCHEMBL7036941 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140929-B1 | 1H-IMIDAZO 4,5-D]PYRIDAZIN-7-ONES, 3H-IMIDAZO 4,5-C]PYRIDIN-4-ONES AND CORRESPONDING THIONES AS CORTICOTROPIN RELEASING FACTOR (CRF) RECEPTOR LIGANDS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6518271-B1 | 1H-imidazo[4,5-d]pyridazin-7-one, and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-11 | — | — | US | disclosed |
| US-6271380-B1 | TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC, NEUROLOGICAL DISORDERS AS WELL IMMUNOLOGICAL, CARDIOVASCULAR OR HEART-RELATED DISEASES AND COLONIC HYPERSENSITIVITY ASSOCIATED WITH PSYCHOPATHOLOGICAL DISTURBANCE AND STRESS. | DUPONT PHARMACEUTICALS COMPANY | 2001-08-07 | — | — | US | disclosed |