Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 18/20 | 0.74 |
| ▸ | CA12 | O43570 | 17/20 | 0.74 |
| ▸ | CA1 | P00915 | 11/20 | 0.74 |
| ▸ | CA2 | P00918 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.56 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.56 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17947763 | 0.85 | CA9 (0.90) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL12585053 | 0.84 | CA9 (0.79) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL23787606 | 0.79 | CA9 (0.85) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL4189849 | 0.78 | CA9 (0.68) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL6929993 | 0.76 | KMT2A (0.62) | RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6926264 | 0.76 | KMT2A (0.72) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL21975646 | 0.76 | CA9 (1.00) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL4016252 | 0.76 | CA9 (0.78) | CA9CA12CA1CA2RAB9A | |
| SCHEMBL24162775 | 0.75 | CA9 (0.70) | CA9CA12CA1CA2RAB9A | |
| Probenecid SCHEMBL20636781 | 0.75 | CA9 (0.97) | CA9CA12CA1CA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624196-B2 | Particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, cardiovascular disorders | WARNER-LAMBERT COMPANY | 2003-09-23 | — | — | US | claimed |
| US-6541521-B1 | Particularly gelatinase A, collagenase-3, and stromelysin-1 | WARNER-LAMBERT COMPANY | 2003-04-01 | — | — | US | claimed |