Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 5/20 | 0.48 |
| ▸ | CES1 | P23141 | 5/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL10618056 | 0.98 | CYP3A4 (0.57) | CYP3A4TDP1CES2CES1ESR1 | |
| Propionic Acid SCHEMBL11597979 | 0.95 | CYP3A4 (0.55) | CYP3A4TDP1CES2CES1ESR1 | |
| Butanone SCHEMBL28691940 | 0.86 | TDP1 (0.55) | CYP3A4TDP1CES2CES1ESR1 | |
| Hydrochloric Acid SCHEMBL8655453 | 0.84 | TDP1 (0.52) | CYP3A4TDP1CES2CES1ESR1 | |
| Hydrochloric Acid SCHEMBL8655450 | 0.84 | TDP1 (0.52) | CYP3A4TDP1CES2CES1ESR1 | |
| Butyric Acid SCHEMBL10589842 | 0.83 | HDAC3 (0.54) | CYP3A4TDP1CES2CES1ESR1 | |
| Succinic Acid SCHEMBL7629002 | 0.81 | CYP3A4 (0.60) | CYP3A4TDP1ESR1ESR2L3MBTL1 | |
| Butyric Acid SCHEMBL10187724 | 0.81 | FFAR3 (0.52) | CYP3A4TDP1CES2CES1ESR1 | |
| Acetic Acid SCHEMBL158139 | 0.80 | CYP3A4 (0.67) | CYP3A4TDP1CES2CES1ESR1 | |
| Alcohol SCHEMBL5271349 | 0.80 | TDP1 (0.67) | CYP3A4TDP1CES2CES1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895122-B1 | A photothermographic material and a method for producing lithographic plates therewith | AGFA GEVAERT (BE) | 2003-12-17 | — | — | EP | disclosed |
| US-5981151-A | IMAGE WISE EXPOSING TO ACTINIC LIGHT A PHOTOTHERMOGRAPHIC MATERIAL COMPRISING ON A SUPPORT A PHOTO-ADDRESSABLE THERMALLY DEVELOPABLE ELEMENT CONTAINING LIGHT-INSENSITIVE ORGANIC HEAVY METAL SALT, PHOTOSENSITIVE SILVER HALIDE | AGFA-GEVAERT, N.V. (BE) | 1999-11-09 | — | — | US | disclosed |
| EP-0895122-A1 | A photothermographic material and a method for producing lithographic plates therewith | AGFA-GEVAERT N.V. (BE) | 1999-02-03 | — | — | EP | disclosed |