Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | PRKCG | P05129 | 2/20 | 0.69 |
| ▸ | CDK1 | P06493 | 2/20 | 0.69 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.69 |
| ▸ | PRKACA | P17612 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | MARK3 | P27448 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | AXL | P30530 | 2/20 | 0.69 |
| ▸ | FLT4 | P35916 | 2/20 | 0.69 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.69 |
| ▸ | GSK3A | P49840 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855185 | 1.00 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6855173 | 1.00 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6855160 | 1.00 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6850583 | 0.87 | AKT1 (1.00) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6850590 | 0.87 | AKT1 (1.00) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL7248362 | 0.87 | AKT1 (1.00) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6851363 | 0.86 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6851376 | 0.86 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6854506 | 0.84 | CHEK1 (0.82) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6849875 | 0.84 | CHEK1 (0.82) | AKT1CHEK1PDPK1DYRK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |