Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | PRKCG | P05129 | 2/20 | 0.69 |
| ▸ | CDK1 | P06493 | 2/20 | 0.69 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.69 |
| ▸ | PRKACA | P17612 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | MARK3 | P27448 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | AXL | P30530 | 2/20 | 0.69 |
| ▸ | FLT4 | P35916 | 2/20 | 0.69 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.69 |
| ▸ | GSK3A | P49840 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850590 | 1.00 | AKT1 (1.00) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6850583 | 1.00 | AKT1 (1.00) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6857510 | 0.90 | AKT1 (0.82) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6851363 | 0.88 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6851376 | 0.88 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6855185 | 0.87 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6855173 | 0.87 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6855160 | 0.87 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6930871 | 0.87 | AKT1 (0.81) | AKT1CHEK1PDPK1DYRK3ROCK2 | |
| SCHEMBL6853402 | 0.86 | AKT1 (0.75) | AKT1CHEK1PDPK1DYRK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199511-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | AKT1 119/4885CHEK1 53/4885PDPK1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.