Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 8/20 | 0.68 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622354 | 0.81 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2MAOBABCB1 | |
| SCHEMBL4622356 | 0.81 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2MAOBABCB1 | |
| SCHEMBL4623436 | 0.81 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2MAOBABCB1 | |
| SCHEMBL29963612 | 0.81 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2MAOBABCB1 | |
| SCHEMBL8483589 | 0.80 | KCNE1 (0.64) | KCNE1KCNQ1KCNH2MAOBMGAT2 | |
| SCHEMBL8483588 | 0.80 | KCNE1 (0.64) | KCNE1KCNQ1KCNH2MAOBMGAT2 | |
| SCHEMBL6938527 | 0.80 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOB | |
| SCHEMBL8486301 | 0.80 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOB | |
| SCHEMBL6938497 | 0.80 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2KCNA5MAOB | |
| SCHEMBL6938528 | 0.80 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |