Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932344 | 0.91 | SLC9A1 (0.39) | SLC9A1KCNH2 | |
| SCHEMBL6933342 | 0.90 | SLC9A1 (0.39) | SLC9A1KCNH2 | |
| SCHEMBL6937267 | 0.90 | SLC9A1 (0.36) | SLC9A1KCNH2 | |
| SCHEMBL6937932 | 0.87 | — | — | |
| SCHEMBL6932303 | 0.87 | MAPT (0.40) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6932302 | 0.86 | SLC9A1 (0.47) | SLC9A1KCNH2 | |
| SCHEMBL6935490 | 0.84 | SLC9A1 (0.39) | SLC9A1KCNH2 | |
| SCHEMBL6935256 | 0.83 | SLC9A1 (0.38) | SLC9A1KCNH2 | |
| SCHEMBL6935062 | 0.83 | ICAM1 (0.40) | SLC9A1KCNH2 | |
| SCHEMBL6935163 | 0.83 | SLC6A2 (0.42) | SLC9A1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |