Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 11/20 | 0.79 |
| ▸ | KCNQ1 | P51787 | 11/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932451 | 1.00 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOBCYP3A4 | |
| SCHEMBL6935186 | 0.90 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOBCYP3A4 | |
| SCHEMBL6935190 | 0.90 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MAOBCYP3A4 | |
| SCHEMBL6932409 | 0.88 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6932410 | 0.88 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6603457 | 0.78 | KCNE1 (0.66) | KCNE1KCNQ1KCNH2MAOBALOX5 | |
| SCHEMBL8479087 | 0.77 | KCNE1 (0.76) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6930496 | 0.76 | KCNE1 (0.73) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6930493 | 0.76 | KCNE1 (0.73) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6935077 | 0.75 | KCNE1 (0.78) | KCNE1KCNQ1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |