Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330862 | 0.96 | DNM1 (0.70) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL331190 | 0.96 | DNM1 (0.70) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| Sulfuric Acid SCHEMBL11672407 | 0.93 | DNM1 (0.65) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL330481 | 0.93 | SLC22A1 (0.65) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| Tetrahexylammonium SCHEMBL330969 | 0.93 | SLC22A1 (0.65) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL331695 | 0.93 | SLC22A1 (0.65) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL330864 | 0.91 | SLC22A1 (0.62) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL11880843 | 0.90 | DNM1 (0.56) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| SCHEMBL4953573 | 0.90 | DNM1 (0.56) | DNM1SLC22A1TSHRHIF1AALDH1A1 | |
| Sulfuric Acid SCHEMBL11672414 | 0.89 | DNM1 (0.60) | DNM1SLC22A1TSHRHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451495-B1 | Toner and developer compositions with charge enhancing additives | XEROX CORPORATION | 2002-09-17 | — | — | US | claimed |
| US-6426170-B1 | Toner and developer compositions with charge enhancing additives | XEROX CORPORATION | 2002-07-30 | — | — | US | claimed |
| US-5591552-A | Toner combination and method and apparatus for use | XEROX CORPORATION (US) | 1997-01-07 | — | — | US | claimed |
| US-5364723-A | Toner compositions with styrene terpene resins | XEROX CORPORATION (US) | 1994-11-15 | — | — | US | claimed |
| US-5114821-A | Toner and developer compositions with charge enhancing additives | XEROX CORPORATION (US) | 1992-05-19 | — | — | US | claimed |
| US-6593049-B1 | Containing charge enhancing additives, which impart or assist in imparting a negative charge to the toner resin particles and enable in embodiments toners with rapid admix characteristics | XEROX CORPORATION | 2003-07-15 | — | — | US | disclosed |
| US-6451495-B1 | Toner and developer compositions with charge enhancing additives | XEROX CORPORATION | 2002-09-17 | — | — | US | disclosed |
| US-6426170-B1 | Toner and developer compositions with charge enhancing additives | XEROX CORPORATION | 2002-07-30 | — | — | US | disclosed |