Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932137 | 0.90 | SLC9A1 (0.48) | SLC9A1 | |
| SCHEMBL6935453 | 0.89 | SLC9A1 (0.50) | SLC9A1KIF18A | |
| SCHEMBL6932550 | 0.88 | SLC9A1 (0.51) | SLC9A1KIF18A | |
| SCHEMBL6932987 | 0.88 | MAPT (0.44) | MAPTHTTSMN1; SMN2SLC9A1KIF18A | |
| SCHEMBL27355044 | 0.88 | MAPT (0.49) | MAPTHTTSMN1; SMN2KIF18ALMNA | |
| SCHEMBL6936292 | 0.85 | SLC9A1 (0.44) | SLC9A1 | |
| SCHEMBL6936197 | 0.85 | SLC9A1 (0.52) | SLC9A1 | |
| SCHEMBL6935337 | 0.83 | SLC9A1 (0.48) | MAPTHTTSLC9A1LMNAPKM | |
| SCHEMBL6937014 | 0.83 | SLC9A1 (0.50) | SLC9A1 | |
| SCHEMBL6936736 | 0.83 | SLC9A1 (0.67) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |