SCHEMBL6933399

SCHEMBL6933399

Cc1cccc(-c2c(N)ccc(N)c2-c2ccccc2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.48
RAB9A P51151 5/20 0.47
CNR1 P21554 2/20 0.46
CNR2 P34972 2/20 0.46
NPC1 O15118 4/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
TSHR P16473 2/20 0.46
HPGD P15428 2/20 0.46
ALDH1A1 P00352 4/20 0.45
ADORA1 P30542 2/20 0.45
HEXA P06865 1/20 0.45
HEXB P07686 1/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KMT2A Q03164 3/20 0.44
NPSR1 Q6W5P4 1/20 0.44
MEN1 O00255 1/20 0.43
DPP4 P27487 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6930975 0.94 RAB9A (0.52) HDAC2RAB9ACNR1CNR2NPC1
SCHEMBL6884583 0.93 ADORA1 (0.44) HDAC2RAB9ACNR1CNR2NPC1
Ammonia Solution, Strong SCHEMBL1411404 0.88 RAB9A (0.45) HDAC2RAB9ACNR1CNR2NPC1
SCHEMBL4058897 0.86 RAB9A (0.46) HDAC2RAB9ACNR1CNR2NPC1
SCHEMBL3869774 0.85 RAB9A (0.52) HDAC2RAB9ACNR1CNR2NPC1
SCHEMBL7164275 0.84 RAB9A (0.47) HDAC2RAB9ACNR1CNR2NPC1
SCHEMBL9681062 0.82 RAB9A (0.48) RAB9ACNR1CNR2NPC1SMN1; SMN2
SCHEMBL25014 0.80 HSD17B10 (0.50) SMN1; SMN2TSHRHPGDALDH1A1ADORA1
SCHEMBL29546125 0.80 HSD17B10 (0.50) SMN1; SMN2TSHRHPGDALDH1A1ADORA1
SCHEMBL10441622 0.79 RAB9A (0.43) HDAC2RAB9ACNR1CNR2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1186595-B1 Diaryl-p-phenylenediamine disulfides GOODYEAR TIRE & RUBBER (US) 2003-11-26 EP disclosed
US-6627686-B1 Mixture with rubber; oxidation resistance; tires, rolls, conveyor belts, footwear THE GOODYEAR TIRE & RUBBER COMPANY 2003-09-30 US disclosed
EP-1186595-A1 Diaryl-p-phenylenediamine disulfides THE GOODYEAR TIRE & RUBBER COMPANY (US) 2002-03-13 EP disclosed
EP-0700963-B1 Polymeric N-aryl substituted and N-alkaryl substituted diphenyldiamines GOODYEAR TIRE & RUBBER (US) 1999-04-14 EP disclosed
US-5726248-A ANTIOXIDANTS FOR DIENE POLYMERS WITH HIGH MOLECULAR WEIGHTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1998-03-10 US disclosed
EP-0700963-A1 Polymeric N-aryl substituted and N-alkaryl substituted diphenyldiamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1996-03-13 EP disclosed