Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650532 | 0.91 | — | — | |
| SCHEMBL168361 | 0.91 | — | — | |
| SCHEMBL48364 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL19359427 | 0.88 | — | — | |
| Water SCHEMBL5331043 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL19359380 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL17873779 | 0.88 | — | — | |
| Hydrogen Peroxide SCHEMBL9062435 | 0.86 | MAP3K14 (0.46) | MAP3K14CYP19A1CRBNMEN1KMT2A | |
| Succinic Acid SCHEMBL28620130 | 0.75 | ITGB1 (0.38) | MAP3K14CYP19A1CRBNMEN1KMT2A | |
| SCHEMBL26620905 | 0.68 | CRBN (0.46) | MAP3K14CYP19A1CRBNMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016659-B1 | Bismaleimides comprising mesogenic groups and oligomeric liquid crystalline bismaleimides | DAINIPPON INK & CHEMICALS (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6169186-B1 | LIQUID CRYSTALS AND LIQUID CRYSTALLINE POLYMERS | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-1016659-A1 | Bismaleimides comprising mesogenic groups and oligomeric liquid crystalline bismaleimides | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2000-07-05 | — | — | EP | disclosed |