SCHEMBL6933800

SCHEMBL6933800

N=C(N)C1(c2ccc(Cl)cc2)C2CC3CC(C2)CC1C3

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 7/20 0.48
ALDH1A1 P00352 1/20 0.41
LMNA P02545 2/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37
KDM1A O60341 1/20 0.37
CHIA Q9BZP6 1/20 0.33
IDO1 P14902 2/20 0.33
EPHX2 P34913 1/20 0.32
P2RX7 Q99572 1/20 0.32
DRD2 P14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6931734 0.98 HSD11B1 (0.47) HSD11B1ALDH1A1LMNAMEN1KMT2A
SCHEMBL6935617 0.83 HSD11B1 (0.48) HSD11B1MEN1KMT2AMAOAMAOB
SCHEMBL6933292 0.83 HSD11B1 (0.64) HSD11B1MEN1KMT2AMAOAMAOB
Hydrochloric Acid SCHEMBL6934108 0.82 HSD11B1 (0.62) HSD11B1MEN1KMT2AMAOAMAOB
Hydrochloric Acid SCHEMBL6935844 0.82 HSD11B1 (0.47) HSD11B1LMNAMEN1KMT2AHTT
Hydrochloric Acid SCHEMBL6934739 0.81 HSD11B1 (0.45) HSD11B1KMT2AMAOB
SCHEMBL6934361 0.80 HSD11B1 (0.51) HSD11B1MAOAMAOBKDM1AIDO1
Hydrochloric Acid SCHEMBL6930671 0.78 HSD11B1 (0.50) HSD11B1MAOAMAOBKDM1AIDO1
SCHEMBL6891957 0.73 HSD11B1 (0.54) HSD11B1ALDH1A1LMNAMEN1KMT2A
Hydrochloric Acid SCHEMBL6935834 0.71 HTR2C (0.40) HSD11B1LMNAMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051392-B1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RES LTD (GB) 2003-12-17 EP claimed
US-6262106-B1 Adamantanecarboximidamide derivatives and their use as NMDA antagonists VERNALIS RESEARCH LIMITED (GB) 2001-07-17 US claimed
EP-1051392-A1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2000-11-15 EP claimed
WO-1999038841-A1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 1999-08-05 WO claimed
EP-1051392-B1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RES LTD (GB) 2003-12-17 EP disclosed
US-6262106-B1 Adamantanecarboximidamide derivatives and their use as NMDA antagonists VERNALIS RESEARCH LIMITED (GB) 2001-07-17 US disclosed
EP-1051392-A1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2000-11-15 EP disclosed
WO-1999038841-A1 ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 1999-08-05 WO disclosed