Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.58 |
| ▸ | PPARG | P37231 | 11/20 | 0.58 |
| ▸ | PPARA | Q07869 | 10/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931405 | 0.91 | PPARD (0.69) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936744 | 0.90 | PPARG (0.60) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936742 | 0.90 | PPARG (0.60) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL5203913 | 0.83 | PPARG (0.52) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6937386 | 0.82 | PPARG (0.84) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6933762 | 0.82 | PPARG (0.69) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936087 | 0.81 | PPARD (0.71) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936091 | 0.81 | PPARD (0.71) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6939657 | 0.80 | PPARG (0.49) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL7074267 | 0.80 | PPARA (0.61) | PPARDPPARGPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |