Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.52 |
| ▸ | HTR2B | P41595 | 14/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14714340 | 0.82 | HTR2C (0.60) | HTR2CHTR2BHTR2A | |
| SCHEMBL2017936 | 0.82 | HTR2C (0.60) | HTR2CHTR2BHTR2A | |
| SCHEMBL2015131 | 0.80 | HTR2C (0.55) | HTR2CHTR2BHTR2A | |
| SCHEMBL692114 | 0.79 | HTR2C (0.48) | HTR2CHTR2BHTR2A | |
| SCHEMBL2018236 | 0.79 | HTR2C (0.48) | HTR2CHTR2BHTR2A | |
| SCHEMBL2018637 | 0.79 | HTR2C (0.78) | HTR2CHTR2BHTR2A | |
| SCHEMBL2558107 | 0.79 | HTR2C (0.78) | HTR2CHTR2BHTR2A | |
| SCHEMBL14714341 | 0.78 | HTR2C (0.53) | HTR2CHTR2BHTR2A | |
| SCHEMBL5747129 | 0.77 | HTR2C (0.56) | HTR2CHTR2BHTR2A | |
| SCHEMBL2562086 | 0.77 | HTR2C (0.52) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |