Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938298 | 1.00 | ACHE (0.33) | ACHEIDH1IDH2 | |
| SCHEMBL14329449 | 0.80 | ACHE (0.34) | ACHE | |
| SCHEMBL14329364 | 0.80 | ACHE (0.34) | ACHE | |
| SCHEMBL19222224 | 0.79 | ACHE (0.39) | ACHE | |
| SCHEMBL25298957 | 0.79 | ACHE (0.36) | ACHE | |
| SCHEMBL17076800 | 0.79 | MEN1 (0.34) | ACHE | |
| SCHEMBL25791839 | 0.79 | ACHE (0.36) | ACHE | |
| SCHEMBL15653049 | 0.79 | MEN1 (0.34) | ACHE | |
| SCHEMBL25791847 | 0.79 | ACHE (0.36) | ACHE | |
| SCHEMBL22531518 | 0.78 | JAK2 (0.39) | ACHEIDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110545-A1 | IMIDAZO [1, 2 -A] PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-15 | — | — | WO | disclosed |