Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539035 | 1.00 | SLC9A1 (0.41) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6938050 | 0.99 | SLC9A1 (0.41) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6935488 | 0.97 | SLC9A1 (0.41) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6935586 | 0.95 | SLC9A1 (0.43) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6937416 | 0.87 | SLC9A1 (0.52) | SLC9A1KCNH2 | |
| SCHEMBL7073430 | 0.87 | SLC9A1 (0.52) | SLC9A1KCNH2 | |
| SCHEMBL6932145 | 0.86 | SLC9A1 (0.53) | SLC9A1KCNH2 | |
| SCHEMBL6935156 | 0.85 | SLC9A1 (0.40) | SLC9A1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6938130 | 0.84 | SLC9A1 (0.51) | SLC9A1 | |
| SCHEMBL6936972 | 0.84 | SLC9A1 (0.53) | SLC9A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |