Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936416 | 0.87 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1PPARGPPARACTSD | |
| SCHEMBL9734780 | 0.83 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1PPARGPPARAPPARD | |
| SCHEMBL6938386 | 0.80 | GRM2 (0.58) | CYSLTR2CYSLTR1PPARGPPARAPPARD | |
| SCHEMBL6935920 | 0.78 | PPARG (0.54) | CYSLTR2CYSLTR1PPARGPPARAPPARD | |
| SCHEMBL5587167 | 0.76 | CYP1A2 (0.38) | CYSLTR2CYSLTR1PPARGPPARAPPARD | |
| SCHEMBL4017548 | 0.76 | HSP90AB1 (0.49) | CYSLTR2CYSLTR1PPARGPPARACTSD | |
| SCHEMBL8262764 | 0.74 | HSP90AB1 (0.43) | CYSLTR2CYSLTR1PPARGPPARACTSD | |
| SCHEMBL8892285 | 0.73 | PPARG (0.45) | CYSLTR2CYSLTR1PPARGPPARAPPARD | |
| SCHEMBL28972724 | 0.72 | TYR (0.41) | CYSLTR2CYSLTR1 | |
| SCHEMBL27375877 | 0.72 | TYR (0.45) | PPARAHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |