Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.54 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 8/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11078874 | 0.88 | PLA2G10 (0.43) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL11084132 | 0.85 | ITGB3 (0.52) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6022912 | 0.83 | PLA2G10 (0.46) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL29997797 | 0.82 | KLK7 (0.51) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL11077466 | 0.82 | PLA2G10 (0.52) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL23459281 | 0.82 | NR1H2 (0.53) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL28974763 | 0.81 | NR1H2 (0.46) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL28974779 | 0.81 | NR1H2 (0.44) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL973127 | 0.81 | KLK7 (0.49) | PLA2G10PLA2G5KLK7NR1H2NR1H3 | |
| SCHEMBL24723803 | 0.80 | KLK7 (0.53) | PLA2G10PLA2G5KLK7NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907643-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| US-5919777-A | PIPERAZINE DERIVATIVES USEFUL FOR TREATING MEDICAL DISORDERS RESULTING FROM A GROWTH HORMONE DEFIENCY | NOVO NORDISK A/S (DK) | 1999-07-06 | — | — | US | disclosed |
| EP-0907643-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997040023-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | disclosed |