Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 5/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061459 | 0.90 | LTA4H (0.53) | HRH1LTA4HNR1H2BAXSLC6A4 | |
| SCHEMBL1696335 | 0.85 | HRH1 (0.67) | HRH1ARLTA4HSLC6A4SLC6A2 | |
| SCHEMBL29815703 | 0.85 | HRH1 (0.67) | HRH1ARLTA4HSLC6A4SLC6A2 | |
| SCHEMBL3179227 | 0.83 | HRH1 (0.59) | HRH1ARSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6938403 | 0.82 | AR (0.49) | HRH1ARSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2202797 | 0.81 | SLC6A2 (0.54) | HRH1ARSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL536921 | 0.80 | LTA4H (0.52) | HRH1LTA4HNR1H2BAXSLC6A4 | |
| Phenol SCHEMBL28832561 | 0.80 | HRH1 (0.51) | HRH1SLC6A4SLC6A2RIPK1 | |
| Phenol SCHEMBL28085319 | 0.80 | HRH1 (0.51) | HRH1SLC6A4SLC6A2RIPK1 | |
| SCHEMBL6062365 | 0.79 | F2 (0.50) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |