Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938201 | 0.89 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6936147 | 0.78 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL8076860 | 0.77 | CA12 (0.37) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL343105 | 0.76 | CA12 (0.40) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6936419 | 0.76 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL4576566 | 0.76 | CA12 (0.36) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL18540700 | 0.76 | BRD4 (0.37) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6934917 | 0.73 | SMN1; SMN2 (0.49) | BRD4L3MBTL1 | |
| SCHEMBL6936373 | 0.72 | CA12 (0.34) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL15242469 | 0.72 | CA1 (0.42) | HSP90AA1HSP90AB1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |