Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 4/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 10/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933038 | 0.83 | PPARD (0.61) | PPARDPLA2G4BPPARGPPARA | |
| SCHEMBL6936584 | 0.82 | PLA2G4B (0.59) | PPARDPLA2G4BPPARGPPARA | |
| SCHEMBL6935592 | 0.82 | FFAR1 (0.50) | PPARDPPARGPPARAFFAR1 | |
| SCHEMBL6936611 | 0.79 | PLA2G4B (0.59) | PPARDPLA2G4BPPARGPPARAFFAR1 | |
| SCHEMBL7911513 | 0.78 | PLA2G4B (0.67) | PLA2G4BFFAR1LTB4RCYP4F2CYP4A11 | |
| SCHEMBL6936964 | 0.78 | PPARG (0.62) | PPARDPLA2G4BPPARGPPARA | |
| SCHEMBL25081990 | 0.76 | PLA2G4B (0.68) | PPARDPLA2G4BPPARGPPARAFFAR1 | |
| SCHEMBL30278815 | 0.76 | PLA2G4B (0.68) | PPARDPLA2G4BPPARGPPARAFFAR1 | |
| SCHEMBL3508233 | 0.75 | PLA2G4B (0.56) | PLA2G4BPPARGPPARAFFAR1LTB4R | |
| SCHEMBL5207075 | 0.75 | PPARG (0.58) | PPARDPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |