Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 6/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515336 | 0.74 | NR1H3 (0.60) | NR1H3PLA2G2ACYP2D6MAPK1L3MBTL1 | |
| SCHEMBL7537497 | 0.69 | CA1 (0.43) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL11209971 | 0.67 | PLA2G4B (0.61) | NR1H3CYP2D6KCNH2 | |
| SCHEMBL6754441 | 0.67 | NR1H3 (0.53) | NR1H3PLA2G2A | |
| SCHEMBL20558774 | 0.66 | L3MBTL1 (0.48) | L3MBTL1NPC1ALDH1A1RAB9A | |
| SCHEMBL20558773 | 0.66 | L3MBTL1 (0.48) | L3MBTL1NPC1ALDH1A1RAB9A | |
| SCHEMBL14499511 | 0.66 | NPC1 (0.50) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL4010528 | 0.66 | TP53 (0.51) | NR1H3CA1CA2CA9MAPK1 | |
| SCHEMBL13357674 | 0.65 | ROCK1 (0.56) | NR1H3 | |
| SCHEMBL16841695 | 0.63 | CA1 (0.63) | CA12CA1CA2CA9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024632-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |