Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23567637 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL2913382 | 0.93 | CHRNB2 (0.55) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL451775 | 0.91 | CHRNB2 (0.68) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL26291025 | 0.89 | CHRNB2 (0.55) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL25989709 | 0.89 | CHRNB2 (0.55) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL26309023 | 0.89 | CHRNB2 (0.55) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL2061289 | 0.85 | CHRNB2 (0.79) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14394408 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL26755668 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4CYP3A4CASP1RECQL | |
| SCHEMBL2916099 | 0.82 | CHRNB2 (0.63) | CHRNB2CHRNA4CYP3A4CASP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021083182-A1 | URICOSURIC AGENT, SYNTHETIC METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 南京明德新药研发有限公司 | 2021-05-06 | — | — | WO | disclosed |
| EP-1101756-B1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-6300366-B1 | FOR THERAPY OF CARDIOVASCULAR DISEASES, ESPECIALLY ARTERIAL HYPERTENSION, ARRHYTHMIA | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-1101756-A1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | disclosed |